Browsing Honors College by Issue Date "2013-11-05"
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- ItemA Semiotic Approach to Ancient Greek Religious Accessories(2013-11-05) Van Arsdale, Alice; Gentile, Kristen; Gulizio, Joann$
- ItemAchilles Tendon Ruptures: a review of the literature(2013-11-05) Newman, Christin; Barfield, William R
- ItemBehavioral and molecular analyses of biological rhythms in Nematostella vectensis(2013-11-05) McPherson, Erin; Meyer-Bernstein, Elizabeth
- ItemColonial Powder Magazines in South Carolina: A Comparative Analysis of the Magazines at Fort Dorchester and Downtown Charleston(2013-11-05) Winkelmann, Brieanna; Borg, Barbara
- ItemEcotourism: A Study of Purchase Proclivity Revisited Across Time and Space(2013-11-05) Pedemonti, Francesca; Litvin, Stephen W
- ItemEnvisioning A Successful and Empowering Model of Sex Education in South Carolina(2013-11-05) Porter, Meredith Margaret; Hladky, Kathleen; DeMaria, Andrea $
- ItemFatherland: Left-wing terrorism presented as the continuation of National Socialist patriarchy in Fassbinder's Die dritte Generation and von Trotta's Die bleierne Zeit(2013-11-05) Rhodes, Stephanie Ann; Nenno, Nancy
- ItemFinancial Industry Diversification: An Empirical Analysis(2013-11-05) von der Lieth, James P; Neesham, BethThis paper uses a quantitative approach to determine whether or not diversified financial institutions perform better than specialized financial institutions for shareholders. It aims to identify whether or not economies of scope benefits of financial conglomerates outweigh the negative implications of providing a wide variety of services. Other academic work has identified economies of scope benefits in the financial sector, including the ability to market diversified services to existing customers, sharing of fixed costs, and ability to take advantage of the moral hazard of the FDIC. (Laeven and Levine) Possible diseconomies of scope effects include exacerbating agency problems between managers and investors, more precarious risk management and invoking inner-company conflicts of interest due to offering both investment services and banking services. This paper will identify which financial institutions business model has historically provided the best returns to shareholders since the repeal of the Glass-Steagall, when United States financial institutions were permitted to diversify their services to the greatest extent since the 1920’s.
- ItemGlutamate Kinetics in a Middle Aged Mouse Model of Parkinson's Disease(2013-11-05) Quattlebaum, Ariana; Korey, Christopher; Boger, Heather$GDNF, a known growth factor, is important for maintaining the health of dopamine (DA) neurons. Parkinson’s (PD) patients have a greatly decreased number of DA neurons in the substantia nigra (SN) while existing nigral neurons have a down regulation of GDNF. Animal models with partial GDNF reduction show an accelerated decline in the SN DA system and motor function similar to PD. Increased glutamate release in the subthalamic nucleus also occurs in PD patients. The purpose of the current study is to help determine the role of glutamate in a GDNF+/- model of PD. Potassium-stimulated glutamate release and uptake in the SN was assessed in anesthetized 12-month-old wild type (WT) and GDNF+/- mice (partial gene knockouts with decreased GDNF levels) by electrochemical detection. After this procedure, western blots helped determine how much glutamate transporter was in each tissue sample, and tissue staining allowed determination of phospho-mTOR levels in the SN (a measure of cellular stress). Initial data indicates high levels of glutamate are released in GDNF+/- tissue, as well as low levels of the transporter GLT-1. Staining results showed an upregulation of phospho-mTOR expression in the SN pars reticulata (SNpr). These results support the idea that glutamate excitotoxicity may play a role in cell death of PD patients, and that cell death leads to additional stress on nearby cells, potentially as an injury response.
- ItemHaussmannization and the change in social mores of Parisian women in the 19th century(2013-11-05) Prados, Myles D; Cuvillier-Hiers, Martine
- ItemIf you are a Monarch butterfly, how do you fly from Canada to Mexico in one lifetime?(2013-11-05) Rumble, Mary E; Southgate, Agnes JMonarch butterflies (Danaus plexippus) are an amazing species that perform the feat of migrating over a thousand miles from Canada to Mexico in one lifetime. We hypothesized that in order to accomplish the migration, the butterflies may have a different flight muscle structure than other insect species. To test this hypothesis, we studied muscle function, and then picked three proteins to analyze through bioinformatics work and PCR/ gel electrophoresis: actin, mp20, and troponin T. We used both the Painted Lady and D. melanogaster as a standard of comparison for our work. We annotated all three of these protein sequences and then checked our findings in the lab. This work showed a recent duplication of the second actin protein in Lepidoptera and differential gene splicing of troponin T in the flight of D. plexippus. Both of these results show the species to have some significant differences in comparison to D. melanogaster.
- ItemInvestigation of the threshold photodynamic dose for HPPH-sensitized PDT of Panc-1 pancreatic cancer cells(2013-11-05) Patel, Pooja M; Jones, LindaOur research group at the College of Charleston has been working in collaboration with physicians at Mayo Clinic to develop a method of drug and light dosimetry for photodynamic therapy (PDT). We are studying Panc-1 pancreatic cancer cells with the photosensitizer 2-[1-Hexyloxyethyl]-2-devinyl Pyrophenophorbide-a (HPPH) and 670-nm light. Our aim is to improve the result of photodynamic therapy (PDT) for the treatment of pancreatic cancer. The first part of the project involved quantifying the photosensitizer using an optical dosimetry method. A “ratio method” was used in which the ratio of the integrated dye fluroesence was divided by the autofluorescence for various amounts of HPPH in a tissue phantom. While dye extraction is likely to overestimate the amount of dye that is therapeutically available in vivo, the ratio method reports optically active photosensitizer content. The second goal of this project was to determine whether there is a threshold of absorbed light for irreversible destruction of photosensitized Panc-1 pancreatic cancer cells. A preliminary experiment compared red and green light sources at an energy dose of 1 Joules/cm2. For the remainder of this project red light was used as it would not limit the depth of the treatment thus, it can penetrate deeper into the tissue to kill the pancreatic cancer cells. The cells were loaded with 1 mg/kg of HPPH and 670-nm light was applied at the range of 0.025-3.0 J/cm2. Clonal assays were used to determine the cell viability, accounting for cell death by both necrosis and apoptosis. After plotting the light absorption dose against cell viability, the LD-50 light dose (light dose that kills 50% of the cells) for HPPH-mediated PDT was determined. The LD50 light dose for panc-1 cells incubated with 1mg/m2 HPPH was 0.15 J/cm2. The dosimetry calculations gave a result of 3.5 x 1010 per cell, yielding an LD-50 dose in terms of photons of 1.11 x 1019 photons per gram of tissue.
- ItemLiminal Spaces and the In-Between: Mobilizing a Queer Resistance within Romantic Literature(2013-11-05) Williams, Andrew Guerrero; Beres Rogers, Kathleen
- ItemMajor Compliance Issues for Japanese Companies in the U.S. Market(2013-11-05) Poletti, Ross A; Wang, Weishen; Blose, Julia$This scholarly paper examines the implications of major compliance issues for Japanese firms conducting business in the U.S. market.
- ItemQueering Femme: An Examination of Contemporary Femme Identity(2013-11-05) Reed, Hannah Clary; O'Dowd, Ornaith; Hladky, Katie$
- Item"I'm Not Like Storybook Girls": Exploring Depictions of Gender in Fantasy Literature(2013-11-05) Winchester, Flannery Kale; Ward, Trish