Browsing Honors College by Issue Date "2013-06-05"
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- ItemDemonstration of the Efficacy of Suberoylanilide Hydroxamic Acid in the Treatment of X-Linked Adrenoleukodystrophy(2013-06-05) Amweg, Kimber Marie; Overby, Jason
- ItemFacebook Knows You: An Analysis of Facebook, Social Anxiety, and Narcissism in Young Adults(2013-06-05) Cifaldi, Olivia; Gutshall, Anne; Kolak, Amy$Participants were recruited via Facebook and administered a brief survey exploring Facebook use, social anxiety, and narcissism. Several significant relationships were found including results supporting prior research on social anxiety, friend selection and activity of use; as well as with narcissism and self-promotion. Overall, an individual's persona on Facebook is related to their real life persona. In addition, those with socially anxious and narcissistic qualities also reflect those qualities online. Recommendations and ideas for future research and practice are discussed.
- ItemFood Deserts in Context: A Look at South Carolina and Charleston(2013-06-05) Conwell, Elizabeth; Knotts, GibbsFor the history of its study, the concept of “food deserts” has been a difficult one to pinpoint. Various definitional challenges suggest a variety of potential ways to study food (in)accessibility in a spatial context. Because this research aims to lay a foundation in the study of food deserts in South Carolina and the Charleston area, the focus of this paper will use statistical analysis to present a preliminary look at where food deserts are located using data from the US Department of Agriculture’s Food Access Research Atlas. Are there any patterns as to where these areas of low access occur? Next, this paper will examine the demographic features of these areas, pairing the 2000 US Census demographic data to the accessibility data. Can we detect any trends in terms of the defining characteristics of these affected communities? Are there “indicators” of potentially low access? Finally, after calculating results for the various levels of analysis, a comparison between local, state, and national conditions of food accessibility will be discussed. How does South Carolina compare to national trends? How does Charleston stack up to other counties in the state? The answers to these questions represent a first step in better understanding food access in South Carolina and the Charleston area. Findings show that South Carolina and Charleston are consistent with national trends as well as previous localized studies.
- ItemFreaking Fatness through History: Critical Intersections of Fatness and Disability(2013-06-05) Cantrell, Amber; Piepmeier, AlisonThis project seeks to explore the connections that are possible between the fields of fat studies and disability studies. Fat studies problematizes the common cultural reading of the fat body as “bad” and medicalized body. Notions of “bad” and pathologized bodies are also explored in disability studies scholarship. However, few scholars are exploring what possibilities lie in the intersection of these two fields of inquiry. In this paper, I will focus on both the historical and modern freak show as platforms for the display of the fat figure. In the first chapter I discuss how historical freak shows provide insight into the construction of the fat figure and the meaning of fatness throughout the nineteenth century. In the second chapter, I shift the lens of analysis from fat women in the historical freak show to portrayals of fatness in the twenty-first century in the reality television show, The Biggest Loser. These two freak show platforms highlight the changing meaning of the fat figure and challenge dominant assumptions about the fat body, proposing instead that the fat figure viewed as a disabled body enables subversive discourse and solidarity.
- ItemGreen Supply Chain Management Practices and Performance in the US and Mexico(2013-06-05) Brooks, Jeffrey T.; Quesada, Gioconda; Gonzalez, Marvin$
- ItemMarx E. Cohen and Clear Springs: Rethinking a Jewish Plantation Owner(2013-06-05) Clare, Seth Reid; Rosengarten, Dale; Mendelsohn, Adam$This essay is a historiographic milestone. It is the first attempt to analyze an antebellum Jewish plantation owner both biographically and in terms of how he managed his plantation on a day-to-day basis. While many historians have supposed that Marx E. Cohen of Charleston was a conventional planter who used Clear Springs to cultivate rice, this essay breaks new ground, arguing that Cohen used Clear Springs as a pleasant county house, rather than a means to an agrarian income.
- ItemMKP‐1 LPS-Driven Osteoclastogenesis More Prevalent in Dusp‐1‐/‐ Females Than Males(2013-06-05) Browne, Courtney G; Valerio, Michael S; Kirkwood, Keith L; Morrison, Susan$Periodontal disease is the result of chronic inflammatory bone loss due to a sustained immune system response to pathogenic invasion. Osteoclasts (OC) are multinucleated, bone resorbing cells that play a vital role in bone turnover. Receptor activator of nuclear factor kappa B ligand (RANKL) is the physiological regulator of osteoclastogenesis (OCgen) in naïve progenitor populations. Gram-negative bacteria involved in pathogenesis of periodontal disease contain the endotoxin, lipopolysaccharide (LPS), which increases RANKL expression by activating innate immune inflammatory cascades including mitogen activated protein kinase (MAPK). MAPK activity is negatively regulated by MAPK phosphatase (MKP)-1 which is encoded by the gene Dusp-1. The current study aims to investigate the role of Dusp-1 when driven by LPS and primed with RANKL OC progenitors (OCP). Based on the role of MKP-1 as a negative regulator of activated MAPK, we hypothesize that Dusp-1 deficient OCP will form more OCs in response to LPS stimuli. OCPs were isolated from male and female hematopoietic stem cells via magnet-activated cell sorting (MACS) and plated (5x104/well) based on expression of CD11b (CD11bhigh, low and neg), from Dusp-1+/+ and Dusp-1-/- mice. Cells were primed with macrophage colony stimulating factor (M-CSF) and RANKL for 48 hours and were then stimulated with 10ng/ml of A. actinomycetemcomitans LPS for up to 4 days. A tartrate resistant acid phosphatase (TRAP) assay was used to visualize formation of OCs at day 0 (M-CSF +RANKL only) and days 2 and 4 post-LPS. Images generated from TRAP were used to determine the number of OCs, number of nuclei per OC, and area per OC. Day 0 cells lacked any exposure to LPS, resulting in minimal variation between Dusp-1+/+ and Dusp-1-/- for all CD11b populations. By Day 2 there was a significant trend of increased female Dusp-1-/- OCgen, with CD11bhigh having the greatest difference (p<0.05). Male data followed an opposite trend, with Dusp-1-/- having less OCgen for all CD11b sorted populations. By Day 4, female CD11bhigh (p<0.0001) and CD11blow (p<0.05) had significantly more OCs for Dusp-1-/-. Day 4 of the males showed a large decrease in Dusp-1+/+ cells, specifically in CD11blow. The data show that LPS induced more osteoclast formation in female Dusp-1-/- mice than Dusp-1+/+ mice. The male Dusp-1+/+ populations show a preliminary increase in OCgen. However, by day 4 there are substantially more Dusp-1-/- cells that are larger than their Dusp1+/+ counterparts. Therefore, these studies indicate that MKP-1 is key negative regulator of MAPK and the subsequent increased OC differentiation promotes inflammatory bone resorption.
- ItemPersonality Trait’s Influence on Priming Helping Behavior(2013-06-05) Bise, Hannah Elizabeth; Swickert, Rhonda
- ItemSources of Congressional Campaign Finance: How Money Can Make a Wealth of Difference(2013-06-05) Bloom, Michelle; Ragusa, Jordan; Curtis, Claire$
- ItemThe Effects of Priming in a Product Placement Context(2013-06-05) Ball, Shelby N; Blose, Julie